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Hassle-free Microscopy Manager -

HMM for Laser Scanning Microscopies

Hassle-free Microscopy Manager -

HMM for Laser Scanning Microscopies

Unlock the Future of Laser Scanning Microscopy with Seamless Integration

The Hassle-Free Microscopy Manager is a revolutionary PCIe and FPGA-based card designed to remove barriers for researchers and innovators working with advanced laser scanning microscopy systems. This cutting-edge solution empowers users to integrate cross-disciplinary resources effortlessly, enabling breakthroughs in microscopy-based research and applications. With compatibility across confocal, multi-photon, STED, TIRF, SNOM, and photoacoustic microscopies, this versatile tool sets a new standard for precision, performance, and ease of use.

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Key Advantages

  • Synchronized System Integration:  HMM simplifies the complexity of synchronizing peripherals such as detectors (e.g., PMT), multi-source lasers, and optomechanical components. By achieving highly synchronized operation, HMM minimizes data discrepancies and reduces system complexity, ensuring a seamless and efficient workflow.
  • Unprecedented High-speed Acquisition: With a signal acquisition rate of 1Gs/s, HMM delivers superior signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). This enables: 1.Higher dynamic range 2.High-speed, streamlined data processing 3.Superior-quality bioimages for advanced research
  • Precision Control: HMM provides unparalleled precision in controlling microscopy systems. Researchers gain accurate manipulation and coordination capabilities, ensuring consistent and reliable experimental setups.
  • Effortless Integration for Hassle-Free Operation: Designed with simplicity in mind, this card easily installs into a PCIe slot, offering true plug-and-play functionality. This minimizes setup time, reduces cross-domain barriers, and streamlines workflows with minimal load on the host PC, allowing researchers to focus more on their core objectives.
  • Optimized for Cutting-Edge Research Tailored for the needs of modern scientific endeavors, HMM enhances the efficiency of experiments and system development. Researchers can now dedicate their time and energy to innovative ideas, free from the burden of complex engineering challenges.

Applications

The Hassle-Free Microscopy Manager is optimized for a broad range of laser scanning microscopy techniques, including Confocal, Multi-photon, STED, TIRF, SNOM, Photoacoustic, etc.. 

Empower Innovation  

By streamlining workflows and reducing engineering complexities, HMM empowers researchers to break through traditional barriers. Whether you're developing novel imaging techniques or advancing interdisciplinary studies, this solution will transform the way you approach laser scanning microscopy.

Contact Us 

Discover how the Hassle-Free Microscopy Manager can elevate your research. Contact us today to learn more or request a demonstration.

Table 1 : HMM for Laser Scanning Microscopy Control Card



Analog input
  • Bit Resolution: 16-bit
  • Channel Number: 4 channels
  • Signal Type: Differential
  •  Sampling Rate: 1GS/s
  • Range: +/- 250mV


Analog output

  • Bit Resolution: 14-bit
  • Channel Number: 4 channels
  • Sampling Rate: 1MS/s
  • Range: +/- 10V


Constant Analog output

  • Bit Resolution: 10-bit
  • Channel Number: 8 channels
  • Range: +/- 10V


Digital IO


  • Channel Number: 4 channels
  • Signal Type: TTL

 
Trigger input

  • Channel Number: 1 channels
  • Signal Type: TTL
  • Clock: 100MHz

 
Trigger output

  • Channel Number: 9 channels
  • Signal Type: TTL
  • Clock: 100MHz

Bus Standard

  • PCIe

 
Connector


  • Analog input SMB x4
  • SCSI – 28pin connector

On Board Memory

  • 4GB


Table 2 : Connector Block



Driving Analog Output
  • BNC x4
  • X-Galvo Driving
  • Y-Galvo Driving
  • Resonant Driving
  • Piezo Z Driving

Detector Input

  • SMB x4

​Detector Gain Output

  • BNC x4

​Laser Power Control

  • BNC x4

 ​Marker Input

  • BNC x4

 ​Resonant Trigger Input

  • BNC



Trigger Output

  • BNC x4
  • Frame Trigger
  • Line Trigger
  • Pixel Clock
  • User Define


Table 3 : Software

Scanning Resolution
  • Galvo-Galvo: 64x64 to 4096x4096
  • Resonance-Galvo: 128x128 to 2048x2048

Controls

  • Laser Analog Control
  • Detector Gain Control

​Scanning Method

  • XY, XYZ, XYT, XYZT


Frame Rate

  • Galvo-Galvo: up to 1fps @512x512 uni-directional scan
  • Resonance-Galvo: up to 16fps @512x512 uni-directional scan with 8kHz resonance scanner

 ​Display Channels

  • Up to 4-ch

 ​Display Modes

  • Split modes
  • Color modes

Software Develop Kit

  • DLL Library  


Table 4 : Others

Cables
  • ​SMB-BNC 2m x4
  • SCSI 28pin Cable 2m

Connector Power  

  • 100-240 VAC to DC Adaptor 



Computer Requirement

  • CPU: Intel I5 or higher
  • RAM: 16 GB or higher
  • HDD: SSD 512 GB or higher
  • OS: Windows 11 or higher
  • With 1 PCIe Gen.4 x8 slot
  • Graphic Card: T400 or Higher



The Significance of HMM to Laser Scanning Microscopies Developers ​​
Breaking Pixel Barriers in High-Speed, Large-FOV Imaging  ​​
Build Your Own Laser Scanning Microscope with TLI-HMM-SC! 


Contact us for more information​​
The Significance of HMM to Laser Scanning Microscopies Developers ​​

Unlock the Future of Laser Scanning Microscopy with Seamless Integration

The Hassle-Free Microscopy Manager is a revolutionary PCIe and FPGA-based card designed to remove barriers for researchers and innovators working with advanced laser scanning microscopy systems. This cutting-edge solution empowers users to integrate cross-disciplinary resources effortlessly, enabling breakthroughs in microscopy-based research and applications. With compatibility across confocal, multi-photon, STED, TIRF, SNOM, and photoacoustic microscopies, this versatile tool sets a new standard for precision, performance, and ease of use.

Contact Us

Key Advantages

  • Synchronized System Integration:  HMM simplifies the complexity of synchronizing peripherals such as detectors (e.g., PMT), multi-source lasers, and optomechanical components. By achieving highly synchronized operation, HMM minimizes data discrepancies and reduces system complexity, ensuring a seamless and efficient workflow.
  • Unprecedented High-speed Acquisition: With a signal acquisition rate of 1Gs/s, HMM delivers superior signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). This enables: 1.Higher dynamic range 2.High-speed, streamlined data processing 3.Superior-quality bioimages for advanced research
  • Precision Control: HMM provides unparalleled precision in controlling microscopy systems. Researchers gain accurate manipulation and coordination capabilities, ensuring consistent and reliable experimental setups.
  • Effortless Integration for Hassle-Free Operation: Designed with simplicity in mind, this card easily installs into a PCIe slot, offering true plug-and-play functionality. This minimizes setup time, reduces cross-domain barriers, and streamlines workflows with minimal load on the host PC, allowing researchers to focus more on their core objectives.
  • Optimized for Cutting-Edge Research Tailored for the needs of modern scientific endeavors, HMM enhances the efficiency of experiments and system development. Researchers can now dedicate their time and energy to innovative ideas, free from the burden of complex engineering challenges.

Applications

The Hassle-Free Microscopy Manager is optimized for a broad range of laser scanning microscopy techniques, including Confocal, Multi-photon, STED, TIRF, SNOM, Photoacoustic, etc.. 

Empower Innovation  

By streamlining workflows and reducing engineering complexities, HMM empowers researchers to break through traditional barriers. Whether you're developing novel imaging techniques or advancing interdisciplinary studies, this solution will transform the way you approach laser scanning microscopy.

Contact Us 

Discover how the Hassle-Free Microscopy Manager can elevate your research. Contact us today to learn more or request a demonstration.

Table 1 : HMM for Laser Scanning Microscopy Control Card



Analog input
  • Bit Resolution: 16-bit
  • Channel Number: 4 channels
  • Signal Type: Differential
  •  Sampling Rate: 1GS/s
  • Range: +/- 250mV


Analog output

  • Bit Resolution: 14-bit
  • Channel Number: 4 channels
  • Sampling Rate: 1MS/s
  • Range: +/- 10V


Constant Analog output

  • Bit Resolution: 10-bit
  • Channel Number: 8 channels
  • Range: +/- 10V


Digital IO


  • Channel Number: 4 channels
  • Signal Type: TTL

 
Trigger input

  • Channel Number: 1 channels
  • Signal Type: TTL
  • Clock: 100MHz

 
Trigger output

  • Channel Number: 9 channels
  • Signal Type: TTL
  • Clock: 100MHz

Bus Standard

  • PCIe

 
Connector


  • Analog input SMB x4
  • SCSI – 28pin connector

On Board Memory

  • 4GB


Table 2 : Connector Block



Driving Analog Output
  • BNC x4
  • X-Galvo Driving
  • Y-Galvo Driving
  • Resonant Driving
  • Piezo Z Driving

Detector Input

  • SMB x4

​Detector Gain Output

  • BNC x4

​Laser Power Control

  • BNC x4

 ​Marker Input

  • BNC x4

 ​Resonant Trigger Input

  • BNC



Trigger Output

  • BNC x4
  • Frame Trigger
  • Line Trigger
  • Pixel Clock
  • User Define


Table 3 : Software

Scanning Resolution
  • Galvo-Galvo: 64x64 to 4096x4096
  • Resonance-Galvo: 128x128 to 2048x2048

Controls

  • Laser Analog Control
  • Detector Gain Control

​Scanning Method

  • XY, XYZ, XYT, XYZT


Frame Rate

  • Galvo-Galvo: up to 1fps @512x512 uni-directional scan
  • Resonance-Galvo: up to 16fps @512x512 uni-directional scan with 8kHz resonance scanner

 ​Display Channels

  • Up to 4-ch

 ​Display Modes

  • Split modes
  • Color modes

Software Develop Kit

  • DLL Library  


Table 4 : Others

Cables 
  • ​SMB-BNC 2m x4
  • SCSI 28pin Cable 2m

Connector Power  

  • 100-240 VAC to DC Adaptor 



Computer Requirement

  • CPU: Intel I5 or higher
  • RAM: 16 GB or higher
  • HDD: SSD 512 GB or higher
  • OS: Windows 11 or higher
  • With 1 PCIe Gen.4 x8 slot
  • Graphic Card: T400 or Higher
The Significance of HMM to Laser Scanning Microscopies Developers​​
Breaking Pixel Barriers in High-Speed, Large-FOV Imaging
Build Your Own Laser Scanning Microscope with TLI-HMM-SC!
Contact us for more information​​

Performance​ Showcase



Images of Neonatal Mouse Brain Slice Using HMM and Digitizer - 2 Photon Microscopy



(Mouse Brain Tissue + GFP)



Images of BPAE Cells Using HMM and Digitizer - 2 Photon Microscopy


(Phalloidin + Alexa Fluor 488 Mitochondria + Red CMXRos) 

How 1GS/s Improves the Image Quality

(Mouse Brain Tissue + GFP)


Images of Neonatal Mouse Brain Slice Using HMM and Digitizer - 2 Photon Microscopy

(Phalloidin + Alexa Fluor 488 Mitochondria + Red CMXRos) 


Images of BPAE Cells Using HMM and Digitizer - 2 Photon Microscopy

How 1GS/s Improves the Image Quality

Quantitative Analysis on SNR with/without HMM

Quantitative Analysis on CNR with/without HMM

Quantitative Analysis on SNR with/without HMM

Quantitative Analysis on CNR with/without HMM